In injection molding the sensitivity to changes in the processing parameters becomes more significant as the part dimensions decrease. Driven by the high cooling rates the interaction between the process, the evolving morphology and the resulting properties is strong, particularly for semi-crystalline thermoplastics. With the help of an experimental design (DoE), the correlation between the process parameters, the morphology and the machine response was compared experimentally and using simulation. For a micro tensile specimen with a shot weight of around 0.04 g good correlations were found for the skin layer formation and the injection pressure. When the skin layer formation dominates, the effect on the mechanical properties is evident.