Local anti-inflammatory drugs are often inadequate in treating skin diseases and especially psoriasis, due to their low dermal permeation capability. Curcumin (CUR) is a TNF-α (Tumor Necrosis Factor) inhibitor that has shown remarkable efficacy in the treatment of psoriasis. In the present study, chitosan nanoparticles were synthesized for curcumin skin-permeating delivery. The ratio of chitosan to the crosslinking agent (tripolyphosphate) was optimized towards obtaining the desired particle size and loading efficiency. Afterwards, the CUR-loaded nanoparticles were incorporated in collagen scaffolds to prepare patches that can be used for the controlled transdermal delivery of CUR. Both pure and crosslinked collagen was used as the matrix of the scaffolds that were prepared by lyophilization. The final patches were characterized in terms of their physicochemical and biological properties as well as the rate of in vitro drug release. Healthy and psoriatic human fibroblasts were used for testing the cytocompatibility of the patches and their potential in inhibiting psoriatic cell proliferation. Results showed that the patches exhibited a controlled release rate of the active compound and preliminary cell studies revealed their potential in inducing apoptosis of psoriatic cells while being cytocompatible with healthy fibroblasts. ACKNOWLEDGEMENTS: Τhe authors wish to acknowledge co-funding of this research by European Union-European Regional Development Fund and Greek Ministry of Education, Research and Religions/EYDE-ETAK through program EPANEK 2014-2020/Action “EREVNO-DIMIOURGO-KAINOTOMO” (project Τ1ΕΔΚ-03798).