Vast amount of oily industrial wastewater has raised a great deal of attention to attempts toward water purification. Water contaminations (organic solvents, oils, and heavy metal ions) can severely interfere with the water quality in which consequently will endanger human’s life. There is an urgent demand toward decontamination of water without further risking the environment or compromising on human health. The conventional methods of water decontamination are often found to be intensive thus require considerable capital investment which precludes their use in much of the real-world applications. There is absolutely a great demand for such an innovative reusable material to replace the current alternatives for water decontamination. In order to decontaminate the wastewater, there is a need for highly porous materials like aerogels which are ultralight weight mesoporous materials. High amount of porosity and small size of their pores make them a great candidate as a high-capacity sorbent material for the purpose of oil sorption. Up to now, various kinds of aerogels have been fabricated, such as carbon nanotube, graphene, and silica aerogels. These lightweight porous materials exhibit interesting properties such as large specific surface area, large pore volume, high degree of porosity, low density, and low thermal conductivity; therefore, they make a promising candidate for a wide range of applications including water decontamination. Yet, the real-life applications of the existing aerogels have been hindered due to the following deficiencies: (I) high cost and complex preparation procedures; (II) high fragility; (III) induced inevitable shrinkage during drying to overcome the damaging effect of large capillary forces that exist during the drying process. In addition, the existing aerogels are mostly non-biodegradable and may cause health problems and environmental challenges. Here, we present a novel, yet straightforward strategy to create PVA-based aerogels inspired by viably available structure in human body, cell walls which selectively operates elements by-passes in and out of the cells. By controlling the pore size, the surface energy, and pore distributi