The presentation reports about the influence of reactive processing on some nanomechanical properties of polyamide 6 (PA6) and its blends with fluoroelastomer (FKM) using PeakForce Quantitative Nanomechanical Mapping (PF-QNM) atomic force microscopy (AFM) technique. PA6 was modified by electron beam (EB) technology within a selected dose range (25-200 kGy) where branching was generated instead of crosslinking. DMT modulus (based on the Derjaguin-Muller-Toporov model) of PA6 was found to increase (~ 131 %), whereas, adhesion force (between tip and sample) and dissipation energy (energy loss) decreased (~ 40 % and ~ 66 %, respectively) with increasing dose (25 and 200 kGy). The changes of above properties with dose were correlated to electron-induced branching, restricted segmental mobility and significant reduction of water absorption. Finally, dynamic vulcanization was used to prepare PA6/FKM Thermoplastic Vulcanizates. Using PF-QNM AFM, DMT modulus and adhesion force were analyzed from the continuous matrix phase to the dispersed domain through the nanometric interface (4 - 5 nm). The effect of dynamic vulcanization on the nanomechanical properties of the interface and the dispersed rubber phase of this blend was also discussed. Systematic investigations are in progress to predict the effect of electron-induced reactive processing on nanomechanical properties of PA6/FKM blends.