Orthopaedic compression screws promote fracture-repair by drawing-together and stabilising adjacent bone fragments. Shape memory polymers (SMP) are smart materials that switch from one macroscopic shape to another following the application of external ‘triggering’ stimuli (e.g. by shrinking in length when heated above Tg). SMP compression screws that shorten in length following surgical implantation (i.e. display body temperature reversion) could potentially pull bone fragments together and thereby facilitate fracture healing. The biocompatible, bioresorbable polymer polylactic acid (Purasorb 7038; PLDLA) shows shape memory properties but the Tg of unmodified PLDLA is too high for body temperature reversion. Accordingly we have used the plasticiser Tributyl O-acetylcitrate (3.5% v/w; TAC) to reduce PLDLA’s Tg and produce a plasticised shape memory material (TAC-PLDLA) that is dimensionally stable at -20°C but which shows shape memory reversion when incubated under physiological conditions (i.e. saline at 37°C). To produce this material, PLDLA and TAC were blended by melt extrusion, pelletized and extruded into 5 mm rods. Shape memory properties were imparted by drawing the rods at 85C, followed by rapid cooling to 4C (draw ratio 4.7, final diameter 2.3 mm). TAC is considered ‘Not hazardous’ according to regulation (EC) No. 1272/2008 and preliminary cell biological studies have shown that the TAC-PLDLA supports viable cell adhesion. This suggests TAC-PLDLA is likely to be biocompatible. A prototype TAC-PLDLA orthopaedic compression screw was designed based upon knowledge of existing metal compression screws and clinical requirements. Aspects of this design (e.g. thread profile) were optimised in silico. Shape memory polymers can be moulded by selective heating and partial reversion within a mould. Subsections of a candidate mould for the proposed screw were therefore designed in silico, and 3D printed in metal. Ongoing work aims to find the optimal time and temperature requirements for reversion moulding an orthopaedic compression screw from a TAC-PLDLA SMP rod. Future work will aim to evaluate the mechanical properties of the resulting device.