pps proceeding - Abstract Preview
pps proceeding
Symposium: S13 - Polymer Materials for Medical Applications
Oral Presentation
 
 

Transparency and suture ability of alginate hydrogel reinforced nanofiber scaffolds

Stafiej Piotr (1)*, Küng Florian (1), Kruse Friedrich E. (1), Fuchsluger Thomas A. (1), Schubert Dirk W. (1)

(1) Friedrich-Alexander-Universität Erlangen-Nürnberg - Bavaria - Germany

The cornea is the outer most and therefore the most compromised part of the eye. The shape, the smoothness and the transparency of the cornea are responsible for 65-75 % of the eye’s focusing. Corneal infection or scarring as result of injuries can lead to restricted or even to loss of vision. For corneal surface treatment the human amniotic membrane is applied traditionally [1]. Possible infections, immunologic reactions, shortcoming in donor tissue and inconsistent mechanical and optical properties are some drawbacks of this membrane. Preparation of synthetic scaffolds caught the interest of clinical research to overcome these disadvantages. Nevertheless most invented scaffolds are not able to fulfill all needed properties like mechanical strength (e.g. suture ability) and optical transparency. In this study we prepared random and aligned nanofiber scaffolds of polycaprolactone (PCL) and its blend with chitosan (CHI) by electrospinning. Sodium alginate hydrogel was incorporated into these membranes to improve the mechanical properties and bring in a possible drug eluting device. UV-Vis transmission spectroscopy was performed in the spectrum of 400 to 800 nm to quantify the transparency of the scaffolds. To visualize the transparency a method described by Schubert et. al. [1] was used. Suture retention strength measurements were performed on the different scaffolds to evaluate the resistance of the scaffolds against the pull-out of a suture [2]. The results demonstrate the semitransparent character as well as the suture ability of our scaffolds what makes them promising candidates for the use in corneal surface treatment [4]. [1] Berthold M.D.; et. al.; Cornea, 2011, 30(3), 269-272 [2] Schubert, D.W.; et. al.; Macromol. Symp., 2016, 365, 87-94 [3] Kueng, F.; et. al.; Mater Sci Eng C, 2016, 69, 941-946 [4] Schubert, D.W.; et. al.; EU-Patent No.:16185130.8-1455