The aim of the present work was to study the influence of the screw configuration in the mixing zone of a co-rotating twin screw extruder on the material properties of a polypropylene talc compound. Highly-filled PP-talc compounds were prepared by means of an industrial Leistritz ZSE27MAXX (48 L/D) twin-screw extruder. Mixing in a twin-screw extruder involves a considerable amount of elongational flow, which is known to be favorable for dispersion of agglomerates. Therefore, high pitch conveying elements as well as eccentric elements were compared to standard kneading blocks. In addition, transition elements from two to triple-flighted screw profiles were used. Subsequently profound material testing was conducted to assess the compound quality. This involved determination of the Filter Pressure Value and the mechanical properties, such as tensile modulus, tensile strength and impact strength. Shear viscosity was measured with a plate-plate-rheometer in order to assess material degradation. Moreover, elongational viscosity of the different compounds was obtained by a High Pressure Capillary Rheometer (HPCR) via Cogswell analysis. In addition, standard quality control tools such as MFR and OIT measurements were performed. With the high pitch conveying elements appealing compound properties could be achieved compare to the standard kneading blocks. In order to achieve high performance compound properties it is necessary to keep dispersion and material degradation in balance, which was achieved by different eccentric screw geometries. While the transition elements show a lower degree of dispersion, indicated by the Filter Pressure Value, they led to promising results in terms of material degradation.