In this study, immiscible blends of 75 wt% polylactic acid (PLA) with 25 wt% of poly[(butylene adipate)-co-terephtalate] (PBAT) and poly[(butylene succinate)-co-adipate] (PBSA) were prepared through injection-molding (IM) as well as twin-screw extruder (TSE) followed by IM. An amorphous and a semi-crystalline PLA were also used as the matrix. The effects of PBAT and PBSA, various processing, and crystalline/amorphous PLA matrices on the morphology development of blends were explored through using a scanning electron microscopy (SEM). Furthermore, the materials and morphological variation influences on the thermal and mechanical properties of PLA-based blends were investigated and compared using a differential scanning calorimeter (DSC), dynamic mechanical analyzer (DMA), and tensile and three-point bending tests, respectively.