In this work, epitaxial growth of high-density polythylene (HDPE) onto lamellae of isotactic polypropylene (iPP), with its lamellae aligned abnormally off the flow direction, has been achieved via pressure vibration injection molding (PVIM). The morphology of epitaxial crystallization was clearly exhibited by scanning electron microscopy (SEM). With the aid of two-dimensional X-ray scattering (2D-WAXS), the specific angles between epitaxial PE lamellae and PP kebab were quantitatively analysised. Unexpectedly, the epitaxial angles were about 56° and would increase with the increase of iPP, which should be attributed to the joint influence of the intense shear field provided by PVIM and the phase transition caused by the variation of blends conposition. In addition, the study on the lamellae developments revealed that there was a matching relationship of lamellae thickness for the epitaxial PE lamellae and the oriented PP lamellae. The VPP60 (60 wt% iPP by weight in blends) shows an optimum lamellae matching relationship, presenting dramatically improvement in both strength and toughness consequently.