The mechanical properties of plastic components, especially if they are made of semi-crystalline polymers, are considerably influenced by the process conditions. The degree of crystallisation influences thermal and mechanical properties. Even more important is the orientation of molecules due to stretching of the polymer melt. Anisotropic material properties are the result of such orientations. Up to now all these effects are not considered within the simulation models of blow moulded parts. The intention of the presented research project is to determine the process-dependent modulus of elasticity in extrusion blow moulded plastic containers made of high-density polyethylene. For own investigations a special blow mould is designed and built. Using this mould parts with very constant wall thickness distribution are produced. In order to determine the process depending elasticity modulus, test specimens are taken from those blow moulded parts. Applied testing methods are the tensile test, three point bending test and the dynamic mechanical analysis (DMA). The test results are statistically analysed by means of the design of experiments method (DOE) and compared with previous conclusions from other scientific papers. Input variables for the statistical investigation are typical process parameters such as the mould temperature, cooling time, degree of stretching and others. The generated data from the DOE study are used to create a material data card for the finite element simulation of the top load test for a plastic bottle. A comparison between the use of standard material data and process specific data shows a significant improvement in simulation accuracy in case of the use of process dependent data. The simulation results are compared with a top load test of a real bottle by the use of optical 3D measurement methods.