In fiber-reinforced plastics (FRP) the matrix material predicts the composite properties regarding bending stiffness, compression behavior, damage behavior, thermal stability, etc. Common FRP structures contain only one matrix systems in the entire part. Hence, the selection of the matrix material is a compromise between the most dominant requirements. To overcome this compromise, the hybrid-matrix approach is investigated using polyurethane (PU) elastomer and thermoset matrix material. This approach offers the possibility to locally integrate the different matrices into one FRP structure using liquid composite molding (LCM) processes. The main challenge of the hybrid-matrix approach is the manufacturing. It needs to guarantee the processing of multiple liquid resin systems with both, defined converging areas of the flow fronts and predictable material properties in the merging area. To investigate suitable process strategies, hybrid-matrix infiltration experiments were performed using LCM processes. For the process assessment the porosity content at the matrix merging areas were analyzed using micrographs. In order to analyze the matrix compatibility and properties in the merging area Tg and bending properties of elastomer/thermoset PU blends were determined. The experiments show that the flow fronts can be controlled and aligned with a predefined geometry within the preform. The comparison of the porosity in the merging area indicates that the material quality is not affected by the merging of the two matrix materials in the manufactured test specimens. The Tg and bending test results show the chemical compatibility and a gradual transition of the mechanical properties in the merging area of the investigated PU blends. The manufacturing of a crash-adaptive FRP prototype structure using the hybrid-matrix approach with both elastomer and thermoset materials illustrates successful integration of two different resin systems within a complex geometry.