pps proceeding
Symposium: Polymer Processing in Pharmacy Keynote Presentation
Sequential Release of Acetylsalicylic Acid and Paclitaxel from Biodegradable Nanofibrous Stents for Promoting Endothelial Recovery and Reducing Neointimal Hyperplasia
Lee Cheng-Hung (1), Liu Shih-Jung (2)*
(1) Chang Gung Memorial Hospital - Tao-Yuan - Taiwan, (2) Chang Gung University - Tao-Yuan - Taiwan
This work develops a biodegradable dual-drug-eluting stents that sequentially and sustainably nanofibrous drug-release anti-platelet acetylsalicylic acid and anti-smooth muscle cells (SMCs) proliferative paclitaxel. To fabricate the biodegradable stents, poly-L-lactide strips are firstly cut from a solvent-casted film. They are rolled onto the surface of a metal pin to form spiral stents. The stents are then consecutively covered by acetylsalicylic acid and paclitaxel-loaded polylactide-polyglycolide nanofibers via electrospinning. Biodegradable stents exhibit superior mechanical properties to metallic stents. The biodegradable stents sequentially release high concentrations of acetylsalicylic acid and paclitaxel for more than 30 and 60 days respectively.