pps proceeding - Abstract Preview
pps proceeding
Symposium: Blends, Reactive Systems & Elastomers
Poster Presentation
 
 

PDMS Surface Immobilization of Hyaluronic Acid: Structure and Properties

Jafar Mazumder Mohammad Abu (1)*

(1) King Fahd University of Petroleum and Minerals - Eastern Province - SaudiArabia

Polydimethylsiloxane (PDMS) elastomers have many advantages, which make them as an evolutionary biomaterial for biomedical and drug delivery applications. PDMS surface was modified by a water soluble, non-toxic and non-immunogenic lubricating polysaccharide, hyaluronic acid (HA). PDMS surface was prepared from sylgrad 184 PDMS pre-polymer using a crosslinking catalyst, which were then modified by incorporating an Si-H bond using (MeHSiO)n followed by the incorporation of allyl amine to amine functionalized modified silicon elastomers. Following the introduction of amine groups at the surface, HA (6.4 kDa) was successfully linked at the surfaces. Attenuated Total Reflection Fourier Transform Infrared Spectroscopy (ATR-FTIR) and water contact angle measurements confirmed that HA was successfully grafted to the PDMS surfaces. Atomic Force Microscopy (AFM) suggested that the PDMS surface was efficiently covered by HA. All modified surfaces exhibited very low water contact angles, which suggested that the HA modified surfaces had increased the hydrophilicity under aqueous conditions relative to the PDMS control. These highly hydrophilic transparent surfaces could have great potential in ophthalmic applications.